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Anisotropic mechanisms for multiphasic unipolar electrograms: simulation studies and experimental recordings
P C Franzone1, L Guerri, M Pennacchio
1Dipartimento di Matematica, Università di Pavia, Istituto di Analisi Numerica del CNR, Italy. colli@dragon.ian.pv.cnr.it
Annals of Biomedical Engineering
|February 24, 2001
Summary
This study simulated epicardial electrograms (EGs) to understand complex wave morphologies. The findings clarify how myocardial architecture influences electrical activity, explaining QRS wave components.
Area of Science:
- Computational electrophysiology
- Cardiac electrophysiology
- Biophysics
Background:
- Unipolar epicardial electrograms exhibit complex morphologies.
- The relationship between these morphologies and myocardial architecture is not fully understood.
Purpose of the Study:
- To elucidate the origin of complex morphologies in unipolar epicardial electrograms.
- To clarify their relationship with myocardial architecture.
Main Methods:
- Simulated electrograms using an anisotropic bidomain heart model.
- Incorporated ellipsoidal geometry, fiber rotation, and Purkinje network.
- Compared simulated electrograms with those recorded from isolated dog hearts.
Main Results:
- Simulated electrograms replicated the multiphasic character of recorded electrograms.
- A split-component model explained wave origins and QRS components.
- Demonstrated the influence of fiber architecture on excitation propagation.
Conclusions:
- Myocardial architecture significantly impacts epicardial electrogram morphology.
- The split-component model enhances understanding of electrical wave propagation.
- Provides insights into the generation of QRS wave features.