Related Experiment Videos
Sildenafil citrate (VIAGRA) improves erectile function in elderly patients with erectile dysfunction: a subgroup
G Wagner1, F Montorsi, S Auerbach
1University of Copenhagen, Division of Sexual Physiology, Rigshospitalet, Denmark.
Summary
Sildenafil effectively treats erectile dysfunction (ED) in elderly men, including those with diabetes. This oral medication demonstrated significant improvements in erectile function with a low incidence of mild side effects.
Area of Science:
- Geriatric Medicine
- Urology
- Pharmacology
Background:
- Erectile dysfunction (ED) prevalence rises with age, notably in elderly men with diabetes.
- Approximately 45% of US men aged 65-69 experience moderate to complete ED.
- The study focused on the efficacy and safety of oral sildenafil for ED in men aged 65 and older.
Purpose of the Study:
- To assess the efficacy and safety of oral sildenafil in elderly men with erectile dysfunction.
- To evaluate sildenafil's effectiveness in both broad-spectrum ED and ED in diabetic patients.
Main Methods:
- Analysis of data from five double-blind, placebo-controlled studies.
- Oral sildenafil administered as needed (not more than once daily) over 12 weeks to 6 months.
- Efficacy assessed via global question, IIEF questions 3 & 4, and IIEF sexual function domains in elderly men (n=411) and elderly men with diabetes (n=71).
Main Results:
- Sildenafil significantly improved erectile function in elderly men with broad-spectrum ED and those with diabetes.
- Common adverse events included mild-to-moderate headache, flushing, and dyspepsia.
- Discontinuation rates due to adverse events were low and comparable to placebo.
Conclusions:
- Oral sildenafil is an effective treatment for erectile dysfunction in elderly men.
- Sildenafil is well-tolerated in this demographic, with a favorable safety profile.