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Assay of fluoxetine hydrochloride by titrimetric and HPLC methods
F Bueno1, A M Bergold, P E Fröehlich
1Departamento de Produção de Matéria-prima, Faculdade de Farmácia, UFRGS. Av. Ipiranga 2752, Porto Alegre, CEP.: 90610-000, RS-Brasil.
Bollettino Chimico Farmaceutico
|February 24, 2001
Abstract:
Two alternative methods were proposed to assay Fluoxetine Hydrochloride: a titrimetric method and another by HPLC using as mobile phase water pH 3.5: acetonitrile (65:35). These methods were applied to the determination of Fluoxetine as such or in formulations (capsules). The titrimetric method is an alternative for pharmacies and small industries. Both methods showed accuracy and precision and are an alternative to the official methods.