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Eudragit matrices for sustained release of ketorolac tromethamine: formulation and kinetics of release
K Ruckmani1, M S Muneera, R Vijaya
1Periyar College of Pharmaceutical Sciences for Girls, Trichy-21.
Abstract:
Matrix type formulations with dicalcium phosphate dihydrate (DCPD) using a polymeric binder (Eudragit RSPM) to obtain controlled release of Ketorolac tromethamine (KT) has been investigated. The drug, DCPD and Eudragit RSPM were granulated using isopropyl alcohol with and without a plasticizer (Diethyl phthalate, DEP). Addition of Eudragit appear to affect the release profile. However, addition of a plasticizer had a significant effect on the rate of release. The release appears to follow first order kinetics and the rate constant decreased linearly with increasing DEP concentration. A directly compressible mixture was also formulated by coating DCPD particles with DEP with and without Eudragit RSPM.
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