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[Production and characterization of an atenolol-reticulated povodone tablet]
J Dobrecky1, C Bregni, M C Lamas
1Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Tecnología Farmacéutica, Junín 956, Piso 6o, (1113) Buenos Aires, Argentina.
Bollettino Chimico Farmaceutico
|February 24, 2001
Abstract:
The production of polymeric complexes in many active drugs with reticulated povidone increased dissolved component percentage. In this work made use a coevaporation technique. Complex formation has been tested by X Ray Diffractometry and Differential Scanning Calorimetry. The percentage of dissolution was determined to the USP XXIII Edition methodology. As can be seen from the results, the Atenolol-reticulated Povidone complexes has greater solubility than the Atenolol mixed with Lactose as excipient.