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[Effect of age on frequency of heteroploidy in human oocytes]
O A Vorob'eva1, M V Bogomolova, T V Kuznetsova
1Ott Institute of Obstetrics and Gynecology RAMN, St. Petersburg.
Tsitologiia
|February 24, 2001
Abstract:
Human oocytes that failed to be fertilized in vitro were fixed for cytogenetic analysis. Successful karyotyping was achieved in 157 oocytes. Among women aged 23-35 years, 34% of oocytes were aneuploid and 8.6% diploid, while for women aged 36-39 years, these values exceeded 41 and 11.8%, respectively. The proportion of aneuploid and diploid oocytes increased significantly as the maternal age advanced. The rate of chromosomal abnormalities with age was analysed using methods of mathematical modelling.