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Published on: May 25, 2017
Infectious diarrhea: pathogens and treatment
1Department of Pathology, University of Utah School of Medicine, Salt Lake City, USA. carrolkc@aruplab.com
Insights
Infectious diarrhea causes millions of deaths annually, especially in young children. Management focuses on hydration, while prevention strategies like vaccines are developing.
Area of Science:
- * Global Health
- * Infectious Diseases
- * Pediatrics
Background:
- * Infectious diarrhea is a leading cause of death worldwide, particularly affecting children under two.
- * It is caused by diverse bacterial, viral, and parasitic pathogens.
- * Disease severity results from a combination of host susceptibility and pathogen virulence.
Purpose of the Study:
- * To review the epidemiology, causes, and management of infectious diarrhea.
- * To discuss current and emerging prevention strategies.
Main Methods:
- * Literature review of infectious diarrhea, focusing on global impact, etiology, and treatment.
- * Analysis of patient management principles, including fluid and electrolyte balance.
- * Evaluation of therapeutic options such as antimotility agents and antimicrobials.
- * Exploration of novel prevention methods, including vaccine development.
Main Results:
- * Diarrhea remains a major global health challenge, with significant mortality in young children.
- * Most cases are self-limiting, with fluid and electrolyte management being critical.
- * Antimotility agents and antimicrobials have specific, often restricted, applications.
- * Vaccine development represents a promising future prevention strategy.
Conclusions:
- * Effective management of infectious diarrhea hinges on addressing fluid and electrolyte imbalances.
- * Judicious use of antimotility agents and antimicrobials is necessary.
- * Preventive measures, particularly vaccines, are crucial for reducing the global burden of infectious diarrhea.
Abstract:
Infectious diarrhea is the most common infectious disease syndrome worldwide resulting in more than five million deaths annually. The greatest morbidity and mortality is seen among children younger than two years of age. A variety of bacterial, viral and parasitic pathogens are responsible for the various syndromes. A combination of host susceptibility and organism virulence factors is responsible for disease. Most episodes of gastroenteritis are self-limited. The hallmark of patient management is strict attention to fluid and electrolyte disturbances. Antimotility agents should be used with caution if at all in children, but may be helpful in adults with travelers' diarrhea. Antimicrobial therapy may shorten the duration of diarrhea in some illnesses, but use is restricted due to emergence of resistance or due to lack of availability in some countries. Newer strategies for prevention include vaccine development.
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