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Related Experiment Videos

Reference ranges for analytes in extravascular body fluids.

W Heil1, J Edelmann, W Kiemstedt

  • 1Central Laboratory of the Klinikum Wuppertal, University of Witten/Herdecke, Germany.

Clinical Laboratory
|February 24, 2001
PubMed
Summary
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Outdated reference values for extravascular body fluids hinder accurate interpretation. This study compiles updated analyte lists for essential body fluids, addressing limitations in older data for modern analytical procedures.

Area of Science:

  • Clinical Chemistry
  • Analytical Biochemistry

Background:

  • Reference values for extravascular body fluids are outdated, with the primary source (Geigy Scientific Tables) dating back to 1981.
  • Many historical analytical methods used for these values are no longer relevant or significant in modern laboratory practice.
  • Applying old reference data to current analytical procedures can lead to misinterpretation of patient results.

Purpose of the Study:

  • To compile an updated list of analytes for essential extravascular body fluids.
  • To provide current reference data suitable for modern analytical procedures.
  • To address the limitations of existing, outdated literature sources.

Main Methods:

  • Extensive literature searches were conducted to identify relevant studies.
  • A critical examination of published data was performed to assess statistical validity, sample size, and plausibility.

Related Experiment Videos

  • The focus was limited to the most essential extravascular body fluids and relevant analytes.

    • Main Results:

    • Only 10-20% of reviewed papers met the criteria for inclusion due to insufficient statistical data, small sample sizes, or lack of plausibility.
    • An updated list of essential analytes for extravascular body fluids was compiled.
    • The study highlights the challenges in establishing reliable reference ranges from existing literature.

    Conclusions:

    • There is a critical need for updated reference values for analytes in extravascular body fluids.
    • Current literature often lacks the necessary rigor for establishing reliable reference ranges for modern clinical use.
    • The findings underscore the importance of critical evaluation of data sources in clinical chemistry.