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Lipid peroxidation in nicotinamide-deficient and nicotinamide-supplemented rats
S S Melo1, M S Meirelles, A A Jordão Júnior
1Dept. of Internal Medicine, Nutrition Division, Faculty of Medicine of Ribeirão Preto, São Paulo University, Av. Bandeirantes 3900, 14049-900 Ribeirão Preto/SP, Brazil.
Abstract:
Supplementation or deficiency of nicotinamide in rats may interfere with the oxidative balance, with excess leading to greater lipid peroxidation, measured by TBARS, and deficiency causing a greater consumption of antioxidants such as vitamin E and glutathione. Urinary N-methylnicotinamide excretion was much more marked in the supplemented group, whereas the difference between deficient and control animals was nonsignificant.