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Primary brain lymphoma presenting as Parkinson's disease
M Sánchez-Guerra1, L Cerezal, C Leno
1Servicio de Neurología, Hospital Universitario Marqués de Valdecilla, Santander, Spain.
Neuroradiology
|February 24, 2001
Summary
Primary brain B-cell lymphoma can present as Parkinson's disease, a rare neurological manifestation. This case highlights the importance of considering neoplastic causes for parkinsonian syndromes unresponsive to standard treatment.
Area of Science:
- Neurology
- Oncology
- Neuroimaging
Background:
- Parkinsonian syndromes are typically associated with neurodegenerative disorders.
- Neoplasms are an uncommon cause of parkinsonism.
- Primary brain lymphoma is a rare central nervous system malignancy.
Observation:
- A woman presented with symptoms mimicking Parkinson's disease.
- Initial neuroimaging revealed lesions in the basal ganglia and corpus callosum.
- The patient's condition progressed with cerebellar and brain-stem signs, and lesions enlarged.
Findings:
- The patient did not respond to levodopa treatment.
- Stereotactic biopsy confirmed high-grade B-cell lymphoma in the basal ganglia.
- The presentation of parkinsonism due to basal ganglia lymphoma is exceptional.
Implications:
- This case underscores the need to consider brain lymphoma in the differential diagnosis of parkinsonian syndromes.
- Early neuroimaging and biopsy are crucial for accurate diagnosis and timely intervention.
- Understanding rare presentations of CNS lymphoma can improve diagnostic accuracy and patient outcomes.