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Related Experiment Videos

Ferritin in formed blood elements (38539).

D A Lipschitz, J D Cook, C A Finch

    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
    |February 1, 1975
    PubMed
    Summary

    Ferritin levels in blood cells were measured, with leukocytes showing the highest concentration. Changes in ferritin mirrored body iron status and increased in mononuclear cells during infection.

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    Area of Science:

    • Hematology
    • Biochemistry
    • Cell Biology

    Background:

    • Ferritin is the primary intracellular iron storage protein.
    • Understanding ferritin distribution in blood components is crucial for diagnosing iron metabolism disorders and inflammatory conditions.

    Purpose of the Study:

    • To quantify ferritin concentration in various blood components.
    • To investigate the impact of iron status and infection on blood ferritin levels.

    Main Methods:

    • Measurement of ferritin concentration in plasma, red blood cells, granulocytes, mononuclear cells (monocytes and lymphocytes), and platelets.
    • Analysis of ferritin changes in conditions of iron depletion, iron overload, and infection.

    Main Results:

    • Similar ferritin amounts were found in plasma, red cells, granulocytes, and mononuclear cells.
    • Leukocytes exhibited the highest ferritin concentrations (approximately 24 mug/ml).
    • Platelets contained negligible ferritin.
    • Ferritin levels changed in response to iron depletion and overload, consistent with general body tissue changes.
    • Infection led to increased ferritin in the mononuclear cell fraction.

    Conclusions:

    • Blood leukocytes are a significant reservoir of ferritin.
    • Ferritin concentration in blood components reflects systemic iron status.
    • Elevated ferritin in mononuclear cells during infection suggests a role similar to that in reticuloendothelial (RE) cells.

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