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[Calcium decreases urinary oxalate]
1Division of Laboratory and Research, National Sanatorium Hyogo Chuo Hospital.
Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
|February 24, 2001
Summary
Active absorbable algal calcium (AAACa) supplementation may reduce urinary oxalate levels more effectively than calcium carbonate. This suggests AAACa could be beneficial in preventing calcium oxalate kidney stone formation.
Area of Science:
- Nephrology
- Urology
- Nutritional Science
Context:
- Kidney stones, particularly calcium oxalate stones, are a common health concern.
- Dietary calcium intake and supplementation are known to influence urinary stone risk factors.
- Understanding the differential effects of various calcium formulations is crucial for prevention strategies.
Purpose:
- To compare the effects of active absorbable algal calcium (AAACa) and calcium carbonate on urinary oxalate excretion and calcium oxalate product.
- To evaluate the potential of AAACa in inhibiting calcium oxalate crystal formation.
- To assess urinary calcium, oxalate, and related parameters in response to different calcium supplements.
Summary:
- A crossover study involving 9 healthy subjects compared 800 mg of AAACa, calcium carbonate, and placebo.
- Urinary calcium excretion was similar for AAACa and calcium carbonate but higher than placebo.
- Urinary oxalate excretion and the calcium-x-oxalate product were lower with AAACa compared to calcium carbonate, suggesting a reduced risk of calcium oxalate stone formation.
Impact:
- AAACa demonstrates a potentially greater efficacy than calcium carbonate in reducing urinary oxalate and the calcium-x-oxalate product.
- These findings suggest AAACa may offer a more effective approach to inhibiting calcium oxalate kidney stone formation.
- Further research into AAACa's role in stone prevention is warranted.