Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Selenium: an insulin-mimetic.

S R Stapleton1

  • 1Department of Chemistry, Western Michigan University, Kalamazoo 49008, USA. stapleton@wmich.edu

Cellular and Molecular Life Sciences : CMLS
|February 24, 2001
PubMed
Summary

Selenium exhibits insulin-like actions, promoting glucose uptake and regulating metabolism. Further research is needed to clarify the exact mechanism by which selenium mimics insulin signaling pathways.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Regulation of proximal tubule sodium/hydrogen antiporter with chronic volume contraction.

American journal of physiology. Renal physiology·2001
Same author

Introduction: the selenium conundrum.

Cellular and molecular life sciences : CMLS·2001
Same author

Snow Grey--a loan draft and new sea legs.

Journal of the Royal Naval Medical Service·2000
Same author

Molecular staging of colorectal cancer: K-ras mutation analysis of lymph nodes upstages Dukes B patients.

Diseases of the colon and rectum·2000
Same author

Inhibitory actions of synthesised polyamine spider toxins and their analogues on Ca2+-activated Cl- currents recorded from cultured DRG neurones from neonatal rats.

Neuroscience letters·1998
Same author

Insulin regulation of glucose-6-phosphate dehydrogenase gene expression is rapamycin-sensitive and requires phosphatidylinositol 3-kinase.

The Journal of biological chemistry·1998

Area of Science:

  • Biochemistry
  • Metabolic Regulation
  • Trace Element Research

Background:

  • Insulin is crucial for glucose uptake and energy storage.
  • Selenium demonstrates insulin-mimetic properties in various studies.
  • Understanding selenium's role in metabolic pathways is essential.

Purpose of the Study:

  • To review and compare the insulin-like actions of selenium.
  • To discuss the evidence supporting selenium as an insulin-mimetic agent.
  • To explore the potential mechanisms of selenium's action.

Main Methods:

  • Literature review of in vivo and in vitro studies on selenium and insulin.
  • Comparison of metabolic effects induced by selenium and insulin.
  • Analysis of selenium's interaction with insulin-signaling proteins.

Main Results:

  • Selenium stimulates glucose uptake and regulates key metabolic processes like glycolysis and gluconeogenesis.
  • Evidence suggests selenium activates proteins within the insulin-signaling cascade.
  • Selenium mimics several critical functions of insulin in cellular metabolism.

Conclusions:

  • Selenium possesses significant insulin-mimetic properties.
  • Selenium's activation of insulin-signaling proteins warrants further investigation.
  • Selenium shows promise as a potential therapeutic agent for metabolic regulation.

Related Experiment Videos