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Liver damage in hemodialysis patients with hepatitis C virus viremia: a prospective 10-year study

N Furusyo1, J Hayashi, Y Kanamoto-Tanaka

  • 1Department of General Medicine, Kyushu University Hospital, Fukuoka, Japan.

Digestive Diseases and Sciences
|February 24, 2001
PubMed

Insights

Hepatitis C virus (HCV) infection significantly impacts hemodialysis patients, causing extensive liver damage. Combined ultrasonography and fibrogenesis markers effectively detect liver damage in HCV-viremic hemodialysis patients.

Area of Science:

  • Hepatology
  • Virology
  • Nephrology

Background:

  • Hepatitis C virus (HCV) infection is a significant concern for patients undergoing hemodialysis.
  • The extent and detection of liver damage in this population require further investigation.

Purpose of the Study:

  • To evaluate the liver damage in hemodialysis patients with chronic HCV infection.
  • To assess the utility of combined diagnostic methods for detecting liver damage.

Main Methods:

  • A cohort of 233 hemodialysis patients was divided into HCV RNA positive (Group X, n=80) and negative (Group Y, n=153) groups.
  • Serial alanine aminotransferase (ALT) levels were monitored from 1989-1998.
  • Serum hyaluronic acid (HA), type-IV collagen (IV-C), platelet counts, and liver ultrasonography were performed in 1998.

Main Results:

  • Group X showed a higher prevalence of continuously abnormal ALT levels and a higher incidence of hepatocellular carcinoma (3 cases).
  • Significantly elevated serum HA and IV-C levels were observed in Group X compared to Group Y (P < 0.05).
  • Ultrasonographic findings correlated with HA levels and platelet counts, revealing more abnormalities in Group X (P < 0.05).

Conclusions:

  • HCV infection leads to significant liver damage in hemodialysis patients.
  • Combined ultrasonography and serum fibrogenesis markers are valuable tools for detecting liver damage in HCV-viremic hemodialysis patients.

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