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Hyperhomocysteinemia in patients with coronary artery disease
N Mahanonda1, W Leowatana, K Bhuripanyo
1Her Majesty Cardiac Center, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Insights
Hyperhomocysteinemia, a condition of high homocysteine levels, is a significant risk factor for coronary artery disease. A total homocysteine (tHcy) level of 11.0 mmol/L best predicts this cardiovascular risk.
Area of Science:
- Cardiovascular Medicine
- Metabolic Disorders
- Atherosclerosis Research
Background:
- Hyperhomocysteinemia is an established risk factor for atherosclerosis.
- Understanding the specific risk of coronary artery disease (CAD) in patients with hyperhomocysteinemia is crucial for clinical practice.
Purpose of the Study:
- To quantify the risk of coronary artery disease (CAD) associated with hyperhomocysteinemia.
- To identify independent risk factors for CAD in this patient population.
Main Methods:
- Retrospective analysis of patient data.
- Statistical evaluation to determine independent risk factors for CAD.
- Assessment of total homocysteine (tHcy) levels for predictive accuracy.
Main Results:
- Age, HDL level, total homocysteine (tHcy) level, and a history of diabetes mellitus (DM) were identified as independent risk factors for CAD.
- A tHcy level of 11.0 mmol/L demonstrated optimal sensitivity and specificity for predicting CAD.
Conclusions:
- Elevated tHcy levels are a significant independent risk factor for CAD.
- The threshold of 11.0 mmol/L for tHcy offers a valuable predictive marker for coronary artery disease.
Abstract:
Hyperhomocysteinemia has been recognized as a risk factor of atherosclerosis. This study was aimed to measure the risk of coronary artery disease in patients with hyperhomocysteinemia. Age, HDL level, tHcy level and history of DM were independent risk factors for coronary artery disease. The level of tHcy of 11.0 mmol/L provides the best sensitivity and specificity of predicting coronary artery disease.