Enantioseparations in super- and subcritical fluid chromatography
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Updated: Oct 9, 2026

Curtain Flow Column: Optimization of Efficiency and Sensitivity
Published on: June 12, 2016
1SmithKline Beecham Pharmaceuticals, Research and Development, King of Prussia, PA 19406, USA. gerald_terfloth@sbphrd.com
Abstract:
The separation of chiral compounds by sub- and supercritical fluid chromatography has been a field of great progress since the first demonstration of a chiral separation by SFC in 1985. Almost all of the chiral selectors used in gas or liquid chromatography have been successfully applied to sub-/supercritical chromatography. Easier and faster method development, high efficiency, superior and rapid separations of a wide variety of analytes, extended-temperature capability, analytical and preparative-scale equipment improvements and a selection of detection options have been reported.
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