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Preparative enantioseparation by simulated moving bed chromatography
Journal of Chromatography. A
|February 24, 2001
Summary
Simulated moving bed (SMB) chromatography, initially for petrochemicals, now excels in enantioseparation. Advances in design, chiral phases, and modeling have driven its production-scale success.
Area of Science:
- Chemical Engineering
- Separation Science
- Chromatography
Background:
- Simulated Moving Bed (SMB) chromatography originated in the petrochemical industry during the 1960s.
- SMB technology is established for large-scale production of petrochemicals and sugars.
Purpose of the Study:
- To review the adaptation of SMB chromatography for enantioseparation.
- To outline new developments in SMB system design and stationary phase technology for chiral separations.
Main Methods:
- Review of existing SMB systems for enantioseparation.
- Analysis of advancements in system design, chiral stationary phase synthesis, and non-linear chromatographic behavior modeling.
Main Results:
- SMB chromatography has been successfully applied to enantioseparation since the early 1990s.
- Numerous SMB separation systems have been implemented in production.
Conclusions:
- Developments in system design, chiral stationary phases, and modeling enabled SMB's adaptation for enantioseparation.
- Ongoing innovations continue to advance SMB technology for chiral separations.