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Murine Cervical Heart Transplantation Model Using a Modified Cuff Technique
Published on: October 12, 2014
Pediatric cardiac retransplantation: intermediate-term results
J A Dearani1, A J Razzouk, S R Gundry
1Loma Linda University Medical Center and Children's Hospital, California. jdearani@mayo.edu
The Annals of Thoracic Surgery
|February 24, 2001
Summary
Pediatric cardiac retransplantation (re-CTx) offers a viable option for failing grafts. Intermediate-term survival after re-CTx is comparable to primary cardiac transplants, indicating acceptable outcomes.
Area of Science:
- Pediatric Cardiology
- Cardiovascular Surgery
- Transplantation Medicine
Background:
- Pediatric cardiac retransplantation (re-CTx) is a complex procedure for failing grafts.
- It remains the optimal treatment for select pediatric recipients.
Purpose of the Study:
- To determine the incidence of re-CTx in a pediatric population.
- To evaluate the outcomes and survival rates of pediatric re-CTx.
Main Methods:
- Retrospective analysis of 347 pediatric cardiac transplant recipients from 1985-1999.
- 22 children underwent re-CTx, with data collected on indications, timing, and outcomes.
Main Results:
- Allograft vasculopathy was the primary indication for re-CTx (n=16).
- Operative mortality was 13.6%, with survival at 3 years at 81.9% +/- 8.9%.
- Intermediate-term survival was similar to primary cardiac transplantation (77.3% +/- 2.6%).
Conclusions:
- Elective pediatric re-CTx can be performed with acceptable operative mortality.
- Intermediate-term survival post-re-CTx is comparable to primary cardiac transplantation in children.
