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Phosphodiesterase 4 isoenzyme inhibitory activity of 3-phenylxanthines and 4-pheny
H Suzuki1, H Sawanishi, K Yamamoto
1Department of Synthetic Chemistry, Faculty of Pharmaceutical Science, Hokuriku University, Kanazawa, Japan. h-suzuki@hokuriku-u.ac.jp
Chemical & Pharmaceutical Bulletin
|February 24, 2001
Abstract:
On the basis of our study on the structure-activity relationships of 1,3,7-alkylxanthines and condensed-purines on cAMP-phosphodiesterase 4 (PDE 4) isoenzyme inhibitor, we investigated the synthesis and the inhibitory activity of 3-phenylxanthine and 4-phenyl[i]condensed-purine derivatives. Xanthines and condensed-purines with the phenyl group exhibited potent and selective PDE 4 inhibitory activity.