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[Cell-mediated immunity after laparoscopic cholecystectomy].

G Di Vita1, C Sciumè, G Lauria Lauria

  • 1Università degli Studi di Palermo Dipartimento di Discipline Chirurgiche Anatomiche ed Oncologiche.

Annali Italiani Di Chirurgia
|February 24, 2001
PubMed
Summary

Major surgery can suppress cell-mediated immunity (CMI). Open cholecystectomy significantly reduced CMI, while laparoscopic cholecystectomy showed no significant changes in immune response.

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Area of Science:

  • Immunology
  • Surgical Oncology

Background:

  • Cell-mediated immunity (CMI) is crucial for immune response.
  • Major surgical procedures can temporarily impair CMI, influenced by anesthesia and intervention specifics.

Purpose of the Study:

  • To evaluate and compare in vivo CMI response after laparoscopic cholecystectomy (LC) versus open cholecystectomy (OC).

Main Methods:

  • 16 patients with gallstones were divided into OC and LC groups.
  • A multi-antigen skin test (Multitest) assessed CMI 48 hours before and 24 hours after surgery.
  • CMI was quantified by the sum of mean diameters (DM) and number of positive antigens (NA).

Main Results:

  • Open cholecystectomy (OC) led to a significant reduction in DM (P < 0.05) and NA (P < 0.05).

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  • Laparoscopic cholecystectomy (LC) did not show significant changes in CMI parameters.
  • No significant differences in age, sex, anesthetic risk, or operation length were noted between groups.

    • Conclusions:

    • Open cholecystectomy significantly suppresses cell-mediated immunity.
    • Laparoscopic cholecystectomy appears to have a minimal impact on CMI.
    • Findings suggest surgical approach influences postoperative immune status.