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[Malignant mediastinal lymph node tumors with unknown primary cancers].

E Faure1, M Riquet, P M Lombe-Weta

  • 1Service de Chirurgie Thoracique, Hôpital Européen Georges Pompidou, Paris, France.

Revue Des Maladies Respiratoires
|February 24, 2001
PubMed
Summary

Patients with malignant mediastinal lymph nodes of unknown primary tumor have a poor prognosis. An aggressive approach including chemotherapy and mediastinal lymph node resection may improve survival rates.

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Area of Science:

  • Oncology
  • Thoracic Surgery

Context:

  • Malignant mediastinal lymph nodes with an unknown primary tumor are rare.
  • This condition presents a diagnostic and therapeutic challenge.

Purpose:

  • To characterize patients with isolated malignant mediastinal lymph nodes.
  • To define an effective therapeutic strategy for this rare malignancy.

Summary:

  • A retrospective study analyzed 54 patients with isolated non-small cell malignancy of mediastinal lymph nodes between 1985 and 1997.
  • Most patients underwent biopsy followed by chemotherapy and/or radiation therapy; 5 had lymph node resection.
  • The 5-year survival rate was 12.4%, with a median survival of 7 months. Primary tumors were identified in only 11.4% of cases.

Impact:

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  • Patients with this condition have a poor prognosis.
  • An aggressive therapeutic approach, including chemotherapy and mediastinal lymph node resection, is recommended to improve survival.
  • Radiation therapy may be used, particularly after incomplete resection.