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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
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Increased plasma adrenomedullin in patients undergoing percutaneous transluminal coronary angioplasty

M Kemal Erol1, Y Genc, A Kiziltunc

  • 1Department of Cardiology and Biochemistry, Ataturk University Hospital Medical School, Erzurum, Turkey. mkerol@superonline.com.tr

Swiss Medical Weekly
|February 24, 2001
PubMed

Insights

Percutaneous transluminal coronary angioplasty (PTCA) significantly elevates plasma adrenomedullin (ADM) levels in patients with coronary artery disease. Coronary angiography alone does not affect ADM levels, suggesting balloon injury triggers cardiac ADM secretion.

Area of Science:

  • Cardiovascular Medicine
  • Endocrinology
  • Interventional Cardiology

Background:

  • Adrenomedullin (ADM) is produced and secreted by endothelial cells.
  • The impact of coronary angiography (CA) and percutaneous transluminal coronary angioplasty (PTCA) on plasma ADM levels is not well understood.

Purpose of the Study:

  • To investigate the effect of CA and PTCA on plasma ADM levels.
  • To determine if ADM levels change following these cardiac procedures.

Main Methods:

  • Plasma ADM concentrations were measured using radioimmunoassay before and after procedures.
  • Patients were categorized into three groups: normal CA, CA for coronary artery disease (CAD), and PTCA for CAD.

Main Results:

  • Plasma ADM levels remained unchanged after CA in patients without CAD (Group I) and with CAD (Group II).
  • PTCA in patients with CAD (Group III) resulted in a significant elevation of plasma ADM levels (p < 0.01).
  • Post-PTCA ADM levels were significantly higher than those observed after CA in both groups.

Conclusions:

  • PTCA, but not CA, leads to increased plasma ADM levels in patients with CAD.
  • The observed increase in ADM following PTCA may be attributed to cardiac secretion from endothelial and smooth muscle cells due to balloon injury.
Abstract

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