Comparison of dioxin-like-response in vitro and chemical analysis of emissions and materials
K W Schramm1, C Klimm, A Hofmaier
1GSF-National Research Center for Environment and Health, Institute of Ecological Chemistry, Neuherberg, Germany. schramm@gsf.de
Abstract:
Samples from industrial and domestic emissions and materials were investigated by using in vitro assays for dioxin-like-response (DLR) and chemical analysis. The results show a small part of persistent bioaccumulative toxicants (PBT) to be responsive in vitro. Clean-up procedures directed to persistence decrease the amount of inducing toxicants substantially. The comparison of biological in vitro (B) and chemical (A) analysis show ratios between B and A below 10 for DLR of persistent inductors. The consideration of PAH improved the knowledge about unknown less persistent agonists.
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