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Mammographic density changes during the menstrual cycle.

G Ursin1, Y R Parisky, M C Pike

  • 1Department of Preventive Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles 90089, USA. gursin@hsc.usc.edu

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
|February 24, 2001
PubMed
Summary
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Mammographic density can increase during the luteal phase of the menstrual cycle, potentially impairing small tumor detection. Premenopausal women may benefit from mammograms during the follicular phase for improved sensitivity.

Area of Science:

  • Radiology
  • Oncology
  • Gynecology

Background:

  • Dense mammograms can obscure small tumors.
  • Mammographic sensitivity may vary with the menstrual cycle phase.

Purpose of the Study:

  • To investigate changes in mammographic density between the follicular and luteal phases.
  • To assess the clinical significance of these density changes.

Main Methods:

  • Studied 11 premenopausal women.
  • Compared mammographic density in follicular vs. luteal phases.

Main Results:

  • Average density increase was 1.2% (P=0.08).
  • Six women experienced significant increases (1.4-7.8%).

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Conclusions:

  • Menstrual cycle phase can affect mammographic density.
  • Scheduling mammograms in the follicular phase may enhance detection for premenopausal women.