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[MRI-assisted brachytherapy of nonresectable liver metastases. Preliminary technical and clinical experiences]
J Kettenbach1, B Pokrajac, S Schamp
1Abteilung für Angiographie und Interventionelle Radiologie, Univ.-Klinik für Radiodiagnostik, Universitätsklinik Wien, Allgemeines Krankenhaus der Stadt Wien, Währinger Gürtel 18-20, 1090 Wien/Osterreich. joachim.kettenbach@univie.ac.at
Purpose:
To evaluate the feasibility and efficacy of MR-guided interstitial brachytherapy of non-resectable liver metastasis.
Methods:
Liver metastases (0.8-5.2 cm in diameter) were treated during a prospective phase I/II study using an open 0.2 Tesla MR system (Magnetom Open Viva, Siemens, Erlangen). MR-compatible brachytherapy applicators were placed percutaneously under MR-guidance in an open 0.2 Tesla MR system (Magnetom Open Viva, Siemens, Erlangen) using fast T1-weighted sequences. Pretreatment and follow-up studies were performed using a 1.5 Tesla MR system.
Results:
Preliminary results of an unpublished prospective study are discussed exemplary on 2 selected patients. The median procedure time was 4.9 h. No major complications were observed and late effects were acceptable. In large symptomatic metastases only a temporary relief of pain was achieved. In smaller metastases (DM 3 cm) a tumor control was observed.
Conclusion:
MR-guided brachytherapy is feasible and has the potential to ablate liver metastases with diameter of less than 3 cm. Further developments are necessary.