[Effect of growth hormone on the structure of bone spongiosa in rats]

Changes in bone spongiosa, which follow after administration of growth hormone (GH) are described differently. Histomorphometrically processed value of bone trabecular volume is found higher or lower than normal. In this study, changes of rat bone spongiosa after administration of GH or bisphosphonate pamidronate were followed. The authors found statistically significant widening of histomorphometric parameter of trabecular thickness, but histomorphometrically assessed values of trabecular bone volume were not statistically different from normal rat bones. The structure of spongiosa is changed, the density of trabecular bone is diminished. The hypothesis of trabecular bone increase after GH administration together with resorption blocking agent (pamidronate) was not confirmed. GH causes widening of bone trabeculae. Pamidronate has no influence on bone histomorphometry in this case.