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Related Experiment Videos

Supratentorial giant cell ependymoma.

J Pimentel1, J J Kepes, J F Moura Nunes

  • 1Laboratório de Neuropatologia, Hospital de Santa Maria, Lisboa, Portugal. cortezpimentel@ip.pt

Clinical Neuropathology
|February 28, 2001
PubMed
Summary
This summary is machine-generated.

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Ependymomas are rare brain tumors. A rare variant with giant cells, found outside the ventricles, suggests prognosis may not always be poor.

Area of Science:

  • Neuro-oncology
  • Pathology

Background:

  • Ependymomas constitute 3-9% of neuroepithelial tumors, typically arising within the ventricular system.
  • Extraventricular ependymomas are less common but can occur in the brain parenchyma.
  • Histologic variants are known, but a giant cell variant receives limited attention.

Observation:

  • A case of a 13-year-old girl with partial seizures presented with an extraventricular, right parietotemporal neoplasm.
  • Cranial MRI revealed a tumor adherent to the dura mater.
  • Histologic, immunohistochemical, and ultrastructural analyses confirmed a high-grade ependymoma.

Findings:

  • The ependymoma was characterized by a predominant component of pleomorphic giant cells.
  • These giant cells share features with those found in pleomorphic xanthoastrocytoma, subependymal giant cell astrocytoma, and glioblastoma multiforme.

Related Experiment Videos

  • Similar giant cell elements have been previously reported in other ependymoma locations.

    • Implications:

    • The presence of isolated giant cells in ependymomas may not invariably indicate a poor prognosis.
    • This case contributes to understanding the spectrum of ependymoma histology and behavior.
    • Further research into giant cell ependymomas could refine diagnostic and prognostic criteria.