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Updated: Oct 9, 2026

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism
Published on: February 14, 2022
[Use of new respiratory technologies in solving problems of artificial one-lung ventilation in thoracic surgery in
Abstract:
The authors proposed a separate independent (or differentiated) artificial lung ventilation as an appropriate alternative variant of artificial lung ventilation (ALV). This approach implies bulky ALV of the operated lung and high-frequency ventilation of the contralateral lung. In patients with associated respiratory diseases and stage II-III respiratory insufficiency, ALV initiates high pulmonary hypertension, intrapulmonary bypass of 50% cardiac output. The differentiated ALV on principal operation stage optimizes homeostatic parameters vs both one-lung and conventional ALV. For patients with stage II-III respiratory insufficiency and cardiovascular disease ALV is contraindicated. Differentiated ALV is the only alternative allowing surgical treatment of lung diseases in high risk patients.
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