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Current status of irinotecan in lung cancer
1Fourth Department of Internal Medicine, Kinki University School of Medicine, Osaka, Japan. mfukuoka@med.kindai.ac.jp
Oncology (Williston Park, N.Y.)
|February 28, 2001
Abstract:
Survival in lung cancer patients has not improved over the past 2 decades. Irinotecan (Camptosar, CPT-11), a semisynthetic analog of the quinoline-based alkaloid camptothecin, is one of several new drugs that have demonstrated promising activity in the treatment of lung cancer in recent years. This article gives a brief overview of the mechanism, development history, and current uses of this agent.