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[Polymethylene derivatives of nucleic bases with omega-functional groups. Pyrimidine derivatives]
A A Makinskiĭ1, A M Kritsyn, E A Ul'ianova
1Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, ul. Vavilova 32, Moscow 117984, Russia.
Bioorganicheskaia Khimiia
|February 28, 2001
Abstract:
N1-Acyclic derivatives of pyrimidine bases (uracil, thymine, and cytosine) with hydrophobic polymethylene chains containing various functional groups in an omega-position of the alkyl substituent were synthesized. Their physicochemical properties and inhibitory effect on the HIV reverse transcriptase and human DNA topoisomerase I were studied.