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Barnidipine monotherapy and combination therapy in older patients with essential hypertension: a long-term study

F B Naber, R Häge, J Mortelmans

    International Journal of Clinical Practice. Supplement
    |February 28, 2001
    PubMed

    Insights

    Barnidipine effectively lowers blood pressure in elderly patients with hypertension. This study found barnidipine monotherapy or combination therapy safe and effective for long-term hypertension management in individuals over 75.

    Area of Science:

    • Gerontology
    • Cardiovascular Medicine
    • Clinical Pharmacology

    Background:

    • Essential hypertension is a prevalent condition in elderly populations.
    • Effective and safe antihypertensive treatments are crucial for managing cardiovascular risk in older adults.

    Purpose of the Study:

    • To evaluate the long-term (2-year) safety and efficacy of barnidipine in patients aged 75 years and older with essential hypertension.
    • To assess barnidipine's effectiveness as monotherapy and in combination with other antihypertensives.

    Main Methods:

    • An open-label, dose-titration, multicentre study involving 236 elderly patients.
    • Barnidipine was initiated at 10 mg daily, with titration to 20 mg if needed. ACE inhibitors or diuretics were added as necessary.
    • Efficacy was measured by changes in sitting diastolic blood pressure (DBP).

    Main Results:

    • An overall response rate of 84.1% was achieved.
    • Mean sitting DBP decreased by 18.4 mmHg from baseline.
    • Barnidipine monotherapy was used in 74% of patients; 37.4% experienced drug-related adverse events.

    Conclusions:

    • Barnidipine is safe and effective for long-term treatment of essential hypertension in elderly patients.
    • Barnidipine can be used as monotherapy or in combination with ACE inhibitors or diuretics.
    • The safety profile is acceptable, with most adverse events related to comorbidities common in the elderly.

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