[Pathogenetic factors of destructive process in trabecular tissues in primary open-angle glaucoma]

Trabecular endothelium and collagen fibers of the posterior wall of Schlemm's channel, obtained in sinusotrabeculectomy from patients with various stages of primary open-angle glaucoma were examined by electron microscopic and biochemical methods. Endothelial cell destruction, damage, rejection, and dissociation in intertrabecular space, progressing in severity, were observed. "Denudation" and degradation of collagen fibers and fibrils were observed. The content of lipid peroxides in aqueous humor and blocks of Schlemm's channel trabecular wall increased from stage to stage, while the level of biogenic antioxidant glutathione decreased.