[Myocardial revascularization may resolve arrhythmic warm-up in patients with implantable cardioverter-defibrillator:...

Patients with ventricular arrhythmias and coronary artery disease may have a poor clinical outcome because of an increased risk of sudden cardiac death. In these patients therapeutic approaches include two main strategies: automatic implantable cardioverter-defibrillator (ICD) and antiarrhythmic drugs (when left ventricular function is preserved). Patients with arrhythmic warm-up sustained by ischemic attacks may be stabilized after percutaneous or surgical revascularization. We report the cases of 2 ICD patients, in whom the correction of myocardial ischemia was successful in preventing further ICD discharges. In the first patient with known coronary artery disease (previous acute myocardial infarction and left ventricular ejection fraction 30%) a sudden arrhythmic warm-up was reported with 70 ICD discharges in 24 hours; the patient underwent coronary artery bypass surgery and only few isolated episodes of ventricular tachycardia were observed during the following 34 months. In the second patient with a history of dorsal acute myocardial infarction and two previous interventions of coronary artery bypass graft surgery, we observed a sudden and unexpected arrhythmic instabilization with several ICD discharges. After percutaneous transluminal angioplasty of a graft stenosis, the clinical situation was stabilized and no more ICD activations were observed during the follow-up. In selected patients arrhythmic warm-up can rely on an ischemic substrate, then a careful re-evaluation for ischemia is mandatory in order to resolve the situation.