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Related Experiment Videos

Imaging findings in pseudocystic osteosarcoma.

M Sundaram1, W G Totty, M Kyriakos

  • 1Department of Radiology, St. Louis University Health Sciences Center, 3635 Vista at Grand, St. Louis, MO 63110-0250, USA.

AJR. American Journal of Roentgenology
|February 27, 2001
PubMed
Summary

Atypical osteosarcoma can mimic benign bone cysts, particularly in females outside the typical age range. These rare cases may present with slow growth, delaying diagnosis.

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Area of Science:

  • Oncology
  • Radiology
  • Pathology

Background:

  • Osteosarcoma typically presents during adolescent growth spurts.
  • Benign bone lesions like simple bone cysts and aneurysmal bone cysts share some imaging features with malignant tumors.

Purpose of the Study:

  • To describe four female patients with osteosarcoma.
  • To highlight cases where osteosarcoma mimicked benign bone cysts radiologically.

Main Methods:

  • Retrospective case series analysis.
  • Review of clinical and imaging findings.
  • Histopathological examination of resected lesions.

Main Results:

  • Four female patients presented with osteolytic, expansile bone lesions without periosteal reaction.

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  • Lesions were initially misdiagnosed as simple or aneurysmal bone cysts.
  • Diagnosis of osteosarcoma was delayed, ranging from 1 week to 3 years post-initial imaging.

    • Conclusions:

    • Atypical osteosarcoma can radiologically mimic benign bone cysts.
    • This presentation may be more common in females and outside the typical age incidence.
    • Microscopic examination revealed conventional and osteoclast-rich osteosarcoma, not cystic or necrotic features.