Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mitochondrial DNA polymorphisms in bipolar disorder.

T Kato1, H Kunugi, S Nanko

  • 1Department of Neuropsychiatry, Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo, Tokyo 113-8655, Japan. tadafumi-tky@umin.ac.jp

Journal of Affective Disorders
|February 27, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A genome-wide association study identifies two novel susceptibility loci and trans population polygenicity associated with bipolar disorder.

Molecular psychiatry·2017
Same author

The neuroprotective effects and possible mechanism of action of a methanol extract from Asparagus cochinchinensis: In vitro and in vivo studies.

Neuroscience·2016
Same author

Increased protein and mRNA expression of resistin after dexamethasone administration.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2014
Same author

Inhibition of olanzapine-induced weight gain by the retinoid analog AM-80.

Pharmacopsychiatry·2013
Same author

Moderating effect of schizotypy on the relationship between smoking and neurocognition.

European psychiatry : the journal of the Association of European Psychiatrists·2012
Same author

Brain-derived neurotrophic factor and glucocorticoids: reciprocal influence on the central nervous system.

Neuroscience·2012
Same journal

The longitudinal relationship between co-rumination and depressive symptoms in adolescents: A systematic review and meta-analytic structural equation modeling.

Journal of affective disorders·2026
Same journal

Child-experienced discrimination and parent mental health in Latino families.

Journal of affective disorders·2026
Same journal

Suicide risk prediction and analysis of associated factors among high school students in four provinces of China based on explainable machine learning.

Journal of affective disorders·2026
Same journal

Integrating hypertriglyceridemia, inflammation, and β-cell stress in clozapine- and olanzapine-associated pancreatitis.

Journal of affective disorders·2026
Same journal

Exploring the functioning trajectories and associated factors in adolescents with first-diagnosis major depressive disorder: Evidence from the sBEAD cohort.

Journal of affective disorders·2026
Same journal

Effects of a self-directed cognitive behavioral therapy manual on depressive symptoms among youths incarcerated for drug-related offenses.

Journal of affective disorders·2026
See all related articles

Mitochondrial DNA (mtDNA) variations, specifically the 5178C/10398A haplotype, are linked to an increased risk of bipolar disorder. Further research is needed to confirm the role of rare mtDNA mutations in the condition.

Area of Science:

  • Genetics
  • Neuroscience
  • Mitochondrial Biology

Background:

  • Previous research suggests mitochondrial abnormalities in bipolar disorder.
  • Evidence includes parent-of-origin effects, altered brain phosphorus metabolism, and increased mitochondrial DNA (mtDNA) deletions.

Purpose of the Study:

  • To investigate the association between mitochondrial DNA (mtDNA) polymorphisms and bipolar disorder.
  • To identify potential genetic risk factors for bipolar disorder within mtDNA.

Main Methods:

  • Examined 12 PCR fragments of mtDNA, including tRNA genes, using single-strand conformation polymorphism in 43 bipolar patients.
  • Sequenced identified polymorphisms and analyzed their association with bipolar disorder using restriction fragment length polymorphism in 135 patients and 187 controls.

Related Experiment Videos

Main Results:

  • Discovered 28 polymorphisms, 14 previously unreported.
  • The A10398G polymorphism showed a significant association with bipolar disorder (P<0.05).
  • The CA haplotype (5178 and 10398) was strongly associated with bipolar disorder (P<0.001), with an odds ratio of 2.4.

Conclusions:

  • The 5178C/10398A haplotype in mitochondrial DNA (mtDNA) may represent a risk factor for bipolar disorder.
  • The pathophysiological significance of rare mtDNA mutations warrants further investigation.
  • These findings suggest a potential role for mtDNA in the pathophysiology of bipolar disorder.