Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Systemic benefits of cyclic ovarian function.

S L Berga1

  • 1Department of Obstetrics, Gynecology, and Reproductive Sciences, The University of Pittsburgh School of Medicine, Magee-Women's Research Institute, Magee-Women's Hospital, Pittsburgh, Pennsylvania 15213, USA. sberga@mail.magee.edu

Journal of the Society for Gynecologic Investigation
|February 27, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CRH receptor antagonism reverses the effect of social subordination upon central GABAA receptor binding in estradiol-treated ovariectomized female rhesus monkeys.

Neuroscience·2013
Same author

Neuropsychological functioning in girls with premature adrenarche.

Journal of the International Neuropsychological Society : JINS·2011
Same author

Impairment of ovarian function and associated health-related abnormalities are attributable to low social status in premenopausal monkeys and not mitigated by a high-isoflavone soy diet.

Human reproduction (Oxford, England)·2010
Same author

Metabolic and reproductive consequences of the serotonin transporter promoter polymorphism (5-HTTLPR) in adult female rhesus monkeys (Macaca mulatta).

Endocrine·2007
Same author

Capacity for 5-HT1A-mediated autoregulation predicts amygdala reactivity.

Nature neuroscience·2006
Same author

The diagnosis and treatment of stress-induced anovulation.

Minerva ginecologica·2005
Same journal

Changes in matrix metalloproteinase 2 activities in amniochorions during premature rupture of membranes.

Journal of the Society for Gynecologic Investigation·2006
Same journal

An animal model of intrauterine growth retardation induced by synthetic thromboxane a(2).

Journal of the Society for Gynecologic Investigation·2006
Same journal

Leptin suppresses human chorionic gonadotropin-induced cyclooxygenase-2 expression and prostaglandin production in cultured human granulose luteal cells.

Journal of the Society for Gynecologic Investigation·2006
Same journal

Chronic tumor necrosis factor-alpha infusion in gravid C57BL6/J mice accelerates adipose tissue development in female offspring.

Journal of the Society for Gynecologic Investigation·2006
Same journal

Genetic associations in preterm birth: a primer of marker selection, study design, and data analysis.

Journal of the Society for Gynecologic Investigation·2006
Same journal

Estrogen metabolite 2-methoxyestradiol induces apoptosis and inhibits cell proliferation and collagen production in rat and human leiomyoma cells: a potential medicinal treatment for uterine fibroids.

Journal of the Society for Gynecologic Investigation·2006
See all related articles

Cyclic ovarian function offers systemic benefits beyond reproduction, impacting nonreproductive tissues like the brain. Understanding these effects is crucial for evaluating hormone therapies and anovulatory states.

Area of Science:

  • Reproductive Endocrinology
  • Neuroendocrinology
  • Women's Health

Background:

  • Cyclic ovarian function, characterized by sex steroid fluctuations, is integral to reproductive processes.
  • The impact of these hormonal changes on nonreproductive tissues, including the brain, is increasingly recognized.

Purpose of the Study:

  • To explore the systemic benefits of cyclic ovarian function.
  • To understand the physiological effects of gonadal steroid exposure on nonreproductive tissues in women.

Main Methods:

  • Review and interpretation of existing data and scientific concepts.
  • Focus on the physiological impact of gonadal steroid exposure on key nonreproductive target tissues.

Main Results:

Related Experiment Videos

  • While reproductive roles are understood, the effects of sex steroid fluctuations on tissues like the limbic lobe and cerebral cortex are less clear.
  • Advances in understanding molecular steroid action reveal complex and subtle impacts on these tissues.

    • Conclusions:

    • A comprehensive understanding of systemic benefits is vital for advising patients on exogenous hormone use for anovulatory states.
    • The complexity of steroid hormone action and numerous target tissues preclude simple risk/benefit assessments of hormonal manipulation.