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Related Experiment Videos

Functional MR imaging and traumatic paraplegia: preliminary report.

P Sabbah1, C Lévêque, F Pfefer

  • 1Radiologie, Hôpital d'Instruction des Armées du Val de Grâce, 75230 Paris. sabbheru@mail.pf

Journal of Neuroradiology = Journal De Neuroradiologie
|February 27, 2001
PubMed
Summary

Functional MRI (fMRI) reveals residual sensorimotor cortex activity in paraplegia patients attempting movement or using mental imagery. This suggests preserved neural pathways despite complete paralysis, confirmed by Somatosensory Evoked Potentials.

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Area of Science:

  • Neuroscience
  • Clinical Neurology
  • Medical Imaging

Background:

  • Paraplegia, resulting from spinal cord injury, often leads to complete loss of motor and sensory function in the lower limbs.
  • Assessing residual neural activity in the sensorimotor cortex is crucial for understanding recovery potential and developing therapeutic strategies.

Purpose of the Study:

  • To investigate residual functional activity within the sensorimotor cortex of the lower limbs in individuals with complete paraplegia.
  • To determine if attempted movements or mental imagery can elicit neural responses in the affected sensorimotor areas.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) was employed in 5 patients with complete paralysis (ASIA A) following traumatic spinal cord injury.
  • fMRI paradigms included attempted toe movements, mental imagery of toe movements, and passive proprioceptive stimulation of the toes.

Related Experiment Videos

  • Control fMRI scans assessed sensorimotor cortex activity during hand movements and stimulation.

    • Main Results:

    • Sensorimotor cortex, premotor cortex, and supplementary motor area (SMA) showed activation during attempted and imagined lower limb movements.
    • Passive somatosensory stimulation elicited responses posterior to the central sulcus in 2 patients.
    • Control studies demonstrated expected sensorimotor cortex activation during hand tasks.

    Conclusions:

    • Attempting to move or mentally evoking movement can generate activity in the sensorimotor cortex of the lower limbs, even in clinically complete paraplegia.
    • fMRI findings indicate the persistence of sensory anatomical conduction pathways, which can be corroborated by Somatosensory Evoked Potentials (SEPs).
    • These results highlight the potential for neuroplasticity and residual function in the sensorimotor system post-spinal cord injury.