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Inverse Probability of Treatment Weighting (Propensity Score) using the Military Health System Data Repository and National Death Index
Published on: January 8, 2020
Sure outcomes of random events: a model for clinical trials
1Institute of Statistics, Université catholique de Louvain, Voie du Roman Pays 20, 1348 Louvain-la-Neuve, Belgium. bouckaert@stat.ucl.ac.be
Abstract:
We consider the outcomes of a clinical trial as determined by one, or several, possibly hidden causes. This paper proposes a statistical model that allows such a distinction of causes not only for the main, or therapeutic, effects but also for the side, or toxic, effects. More specifically, we focus on trials where the effects are naturally dichotomized, that is, where the health of a patient has improved or not, and where a specific adverse effect has occurred or not. A case study provides an example of the way this model can help to solve some problems of suspected drug toxicity. Finally, the model is shown to be a part of a hierarchy of models and the way to select a best model is investigated.
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