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Chronic treatment with clomipramine and mianserin increases the hierarchical position of subdominant rats housed in

P.J. Mitchell1, P.H. Redfern

  • 1Pharmacology Group, School of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, Avon BA2 7AY, UK.

Behavioural Pharmacology
|June 1, 1992
PubMed
Summary

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Antidepressant drugs clomipramine and mianserin increased the social dominance of subordinate rats. This suggests potential antidepressant effects by altering social behavior and hierarchy in male Wistar rats.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Animal Behavior

Background:

  • Social behavior in male Wistar rats is hierarchical, with dominant, subdominant, and subordinate individuals.
  • Social interactions and hierarchy are observable at the onset of the dark phase under a 12h:12h light-dark cycle.

Purpose of the Study:

  • To investigate the effects of chronic antidepressant treatment on social hierarchy in male Wistar rats.
  • To determine if clomipramine and mianserin can alter dominance and subordinate behaviors.

Main Methods:

  • Male Wistar rats were housed in triads and observed during social interactions.
  • Subdominant rats received chronic treatment with clomipramine or mianserin via osmotic mini-pumps.
  • Social hierarchy was assessed by the proportion of wins during social encounters.

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Main Results:

  • Chronic treatment with clomipramine and mianserin significantly increased the proportion of wins for subdominant rats.
  • This increase in wins by subdominant rats occurred at the expense of the dominant rat's status.
  • The observed changes in social dominance were maintained throughout the treatment period.

Conclusions:

  • Clomipramine and mianserin demonstrate antidepressant activity by modulating social behavior and hierarchy.
  • The findings suggest a link between antidepressant efficacy and the ability to influence social agonistic behavior.
  • Antidepressant-induced changes in social dominance may serve as an indicator of therapeutic effects.