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Related Experiment Videos

Small-bowel motility.

Silvia Delgado Aros1, Michael Camilleri

  • 1Enteric Neuroscience Group, Gastroenterology Research Unit, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA.

Current Opinion in Gastroenterology
|February 27, 2001
PubMed
Summary
This summary is machine-generated.

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Recent advances in small-bowel motility research highlight the intrinsic primary afferent neuron

Area of Science:

  • Gastroenterology and Neurogastroenterology

Background:

  • Small-bowel motility research has advanced significantly, clarifying the roles of intrinsic primary afferent neurons, enteric nervous system development, and interstitial cells of Cajal.
  • Serotonin receptor modulators represent promising therapeutic avenues, particularly for motility disorders.

Purpose of the Study:

  • To review recent human studies on small-bowel motility.
  • To emphasize novel methodologies, disease manifestations, and therapeutic strategies in the field.

Main Methods:

  • Review of recent human studies focusing on small-bowel motility.
  • Analysis of novel methodologies and therapeutic strategies.

Main Results:

  • Delineation of the intrinsic primary afferent neuron's role in peristalsis.

Related Experiment Videos

  • Understanding the genetic control of enteric nervous system development.
  • Recognition of interstitial cells of Cajal as intestinal pacemakers.
  • Identification of serotonin (5-hydroxytryptamine) receptor modulators as key therapeutic agents, especially for irritable bowel syndrome.

    • Conclusions:

    • Novel insights into small-bowel motility mechanisms have emerged.
    • Serotonin receptor modulation offers significant therapeutic potential for gastrointestinal disorders.
    • Human studies are crucial for advancing our understanding and treatment of motility disorders.