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Related Experiment Videos

Selenium: recent clinical advances.

Raymond F. Burk1

  • 1Division of Gastroenterology, Department of Medicine and Clinical Nutrition Research Unit, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.

Current Opinion in Gastroenterology
|February 27, 2001
PubMed
Summary

Selenium is a vital trace element with essential metabolic functions. Suboptimal selenium intake worldwide may lead to health issues, including increased viral virulence and potential cancer prevention benefits.

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Area of Science:

  • Nutritional Science
  • Biochemistry
  • Public Health

Background:

  • Selenium is an essential trace element crucial for numerous metabolic functions.
  • Recommended dietary allowance (RDA) for adults is 55 µg/day.
  • While deficiency is rare in the US and Canada, suboptimal intake is prevalent globally.

Purpose of the Study:

  • To highlight the global health implications of suboptimal selenium intake.
  • To discuss the link between selenium deficiency and increased viral virulence.
  • To explore the potential of selenium as a cancer chemopreventive agent.

Main Methods:

  • Literature review of existing studies on selenium metabolism and deficiency.
  • Analysis of the impact of selenium status on viral pathogenicity.

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  • Examination of epidemiological data on selenium intake and disease prevalence.
  • Review of clinical trials investigating selenium supplementation for cancer prevention.

    • Main Results:

    • Suboptimal selenium intake can lead to clinical consequences and may enhance viral virulence.
    • Populations in regions like China with lower selenium levels are susceptible to infections by more virulent viruses.
    • Preliminary evidence suggests selenium may have cancer chemopreventive properties at supranutritional doses.

    Conclusions:

    • Global selenium status is a significant public health concern due to its role in immunity and disease.
    • Further research, including ongoing studies, is crucial to fully understand selenium's role in health and disease prevention.
    • Adequate selenium intake is vital for mitigating risks associated with infectious diseases and potentially cancer.