Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

New combination therapies for asthma.

J F Donohue1, J A Ohar

  • 1Pulmonary Division, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599-7020, USA. jdonohue@med.unc.edu

Current Opinion in Pulmonary Medicine
|February 27, 2001
PubMed
Summary

Combination therapies offer significant clinical benefits for asthma management by combining medications with complementary actions. This approach effectively reduces asthma exacerbations and improves patient symptoms, supported by extensive clinical data.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

User-centered design of a COPD care pathway for patients with cancer: a mixed-methods clinical trial protocol.

Future oncology (London, England)·2025
Same author

Timing of radiotherapy (RT) after radical prostatectomy (RP): long-term outcomes in the RADICALS-RT trial (NCT00541047).

Annals of oncology : official journal of the European Society for Medical Oncology·2024
Same author

A comprehensive care plan that reduces readmissions after acute exacerbations of COPD.

Respiratory medicine·2018
Same author

Tadalafil therapy for sarcoidosis-associated pulmonary hypertension.

Pulmonary circulation·2017
Same author

Efficacy and safety of once-daily umeclidinium/vilanterol 62.5/25 mcg in COPD.

Respiratory medicine·2013
Same author

Ambrisentan for sarcoidosis associated pulmonary hypertension.

Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG·2011

Area of Science:

  • Pulmonology
  • Pharmacology

Background:

  • Asthma management often requires combination therapy due to the complex pathophysiology of the disease.
  • Different therapeutic agents possess complementary mechanisms of action beneficial for controlling asthma.

Purpose of the Study:

  • To review the scientific rationale and clinical benefits of various combination therapies for asthma.
  • To highlight the efficacy of combining different drug classes in improving asthma control and reducing exacerbations.

Main Methods:

  • Review of scientific literature and clinical trial data on asthma combination therapies.
  • Analysis of the complementary mechanisms of action for different asthma medications.

Main Results:

  • Combination of long-acting beta(2)-agonists and inhaled corticosteroids effectively reduces asthma exacerbations and improves symptoms.

Related Experiment Videos

  • Inhaled corticosteroids combined with leukotriene-receptor antagonists or antihistamines offer additional therapeutic benefits.
  • Older agents like theophylline and controlled-release albuterol can be added to inhaled corticosteroids to potentially reduce steroid dosage.

    • Conclusions:

    • Combination therapy is a valuable strategy in asthma treatment, leveraging complementary mechanisms for enhanced efficacy.
    • Ongoing research continues to explore novel combination approaches for improved asthma control.