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Herpes simplex virus-1 encephalitis in eastern Uttar Pradesh
I S Gambhir1, N N Singh, D S Singh
1Dept. of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221 005, India.
The Journal of the Association of Physicians of India
|February 28, 2001
Summary
Herpes Simplex Virus type 1 (HSV-1) encephalitis is rare in acute viral encephalitis cases in Eastern Uttar Pradesh, India. This study found HSV-1 encephalitis in only 1.1% of patients with acute viral encephalitis.
Area of Science:
- Neurology
- Infectious Diseases
- Virology
Background:
- Acute viral encephalitis is a serious neurological condition with various potential causes.
- Herpes Simplex Virus type 1 (HSV-1) is a known cause of encephalitis, but its prevalence varies geographically.
- Understanding the etiological spectrum of encephalitis is crucial for appropriate diagnosis and management.
Purpose of the Study:
- To determine the proportion of Herpes Simplex Virus type 1 (HSV-1) encephalitis among patients diagnosed with acute viral encephalitis.
- To assess the incidence of HSV-1 encephalitis in a specific region of India.
Main Methods:
- A study included 105 patients with a clinical diagnosis of acute viral encephalitis.
- Cerebrospinal fluid (CSF) samples from 90 patients were tested for HSV-1 IgM antibodies using ELISA.
- Computed Tomography (CT) scans and Electroencephalogram (EEG) studies were performed on 25 patients.
Main Results:
- Clinical and neuro-investigational findings suggested a low incidence of HSV-1 encephalitis.
- Only one patient (1.1%) tested positive for HSV-1 IgM antibodies in their CSF sample.
Conclusions:
- Herpes Simplex Virus type 1 (HSV-1) encephalitis accounts for a very small proportion of acute viral encephalitis cases in Eastern Uttar Pradesh, India.
- The findings highlight the need for regional epidemiological data to guide diagnostic and treatment strategies for encephalitis.