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From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia
Published on: October 19, 2014
[Clinical analysis of 10 cases of true histiocytic lymphoma]
Objective:
To explore the clinical and pathological characteristics of true histiocytic lymphoma.
Methods:
The clinical and pathological data of 10 true histiocytic lymphoma patients admitted between 1986 and 1996 to our hospital was retrospectively reviewed.
Results:
True histiocytic lymphoma accounted for 0.6% of non-Hodgkin's lymphoma(NHL) admitted in this period to our hospital. Enzymes associated with true histiocytic lymphoma were detected in all the 10 cases. The tumor cells were excluded from T/B lymphoid origin in 6 cases by immunohistochemistry. Eight cases received chemotherapy + irradiation +/- excision of primary lesion, 1 simply received irradiation and 1 received bone marrow transplantation. The response rate was 100%, with a 1, 3 and 5 year survival rate of 100%, 90% and 70%, respectively. The expected 10 year disease free survival rate is 40%.
Conclusion:
True histiocytic lymphoma is a rare subset of NHL. Those originated from lymph node are sensitive to chemotherapy and irradiation with a favorable prognosis.
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