[Current research status of anti-influenza chemotherapy]

Current progress in anti-influenzavirus chemotherapy has lead us to clinical use of amantadine and NA inhibitors such as zanamivir and oseltamivir. In order to overcome the problems of resistant virus which may appear for these drugs, we are in demand to develop new anti-influenza drugs which have other target points than uncoating or NA activity of the virus. Several compounds under investigation which inhibit conformational change of HA under low pH, endonuclease activity to provide cap of m-RNA, antisense oligonucleotide stable for digestion by endonuclease, artificially synthesized Zn-finger motif peptide etc were reviewed.