Related Experiment Videos
Neuroprotective aspects of a novel MAO-B inhibitor PF9601N
1Departament de Bioquímica i de Biologia Molecular, Facultat de Medicina, Universitat Autònoma de Barcelona, 08193 Bellalterra, Spain.
Abstract:
PF9601N is an acetylenic tryptamine derivative devoid of amphetamine-like properties, that behaves as suicide MAO-B inhibitor more potent than l-deprenyl. It is highly selective towards MAO-B and it neuroprotects from the neurotoxicity induced in C57Bl/6 adult mice by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). PF9601N also shows in vitro antioxidant properties by inhibiting the dopamine autoxidation. A potential therapeutic use in Parkinson's disease treatment is proposed for this compound.
Related Concept Videos
Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists