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Related Experiment Video

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A Simple Fluorescence-based Reporter Assay to Identify Cellular Components Required for Ricin Toxin A Chain RTA Trafficking in Yeast
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Abrin and hurin: two new lymphocyte mitogens.

S J Kaufman, A McPherson

    Cell
    |March 1, 1975
    PubMed
    Summary

    Abrin and hurin are potent plant-derived lymphocyte mitogens that stimulate mouse spleens more effectively than PHA or PWM. These plant proteins require thymus-derived lymphocytes for their mitogenic activity.

    Area of Science:

    • Immunology
    • Plant Biochemistry

    Background:

    • Plant proteins abrin and hurin are known mitogens.
    • Their mitogenic potency and requirements are not fully elucidated.

    Purpose of the Study:

    • To compare the mitogenic potential of abrin and hurin with established mitogens like PHA and PWM.
    • To investigate the cellular requirements for abrin and hurin-induced lymphocyte stimulation.

    Main Methods:

    • Purification and characterization of abrin.
    • Assessment of lymphocyte proliferation in mouse spleen cells (BALB/C and CBA strains) stimulated by abrin, hurin, PHA, and PWM.
    • Evaluation of the role of thymus-derived lymphocytes in the response.

    Main Results:

    • Both abrin and hurin demonstrated potent mitogenic activity, significantly exceeding that of PHA and PWM.

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  • Thymus-derived lymphocytes were essential for the observed stimulation by abrin and hurin.
  • Abrin was purified to electrophoretic homogeneity and showed potential conversion from a toxic to a mitogenic form.
  • Hurin was identified as the most effective mitogen tested.

    • Conclusions:

    • Abrin and hurin are highly potent lymphocyte mitogens requiring thymus-derived lymphocytes.
    • Hurin represents a particularly effective mitogen for immunological studies.
    • Further research into abrin's toxic-to-mitogenic conversion may yield novel insights.