Jove
Visualize
Contact Us

Related Experiment Videos

The Daxx enigma.

J S Michaelson1

  • 1Department of Genetics, Harvard Medical School, Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA.

Apoptosis : an International Journal on Programmed Cell Death
|February 28, 2001
PubMed
Summary

The protein Daxx

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

T cell engagers emerge as a compelling therapeutic modality.

The Journal of experimental medicine·2025
Same author

Evaluation of the addition of rituximab to CODOX-M/IVAC for Burkitt's lymphoma: a retrospective analysis.

Annals of oncology : official journal of the European Society for Medical Oncology·2011
Same author

Development and validation of a model predictive of occult nipple involvement in women undergoing mastectomy.

The British journal of surgery·2008
Same author

Matched pair analyses of stage IV breast cancer with or without resection of primary breast site.

Annals of surgical oncology·2008
Same author

Age-dependent effects of TWEAK/Fn14 receptor activation on neural progenitor cells.

Journal of neuroscience research·2007
Same author

Spread of human cancer cells occurs with probabilities indicative of a nongenetic mechanism.

British journal of cancer·2005
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Area of Science:

  • Cellular biology and molecular mechanisms.

Background:

  • The precise function of Daxx protein remains elusive, with conflicting reports on its role in apoptosis.
  • Daxx's involvement in transcription and centromere binding is also uncertain.
  • The protein's lack of homology to known proteins complicates research.

Purpose of the Study:

  • To elucidate the multifaceted roles of Daxx within cellular processes.
  • To clarify Daxx's direct or indirect involvement in apoptosis.
  • To investigate potential alternative functions of Daxx.

Main Methods:

  • Yeast-interaction trap systems were employed to identify Daxx-interacting molecules.
  • Analysis of existing literature to synthesize current understanding of Daxx.

Main Results:

  • Daxx interacts with a diverse range of molecules, leading to speculative roles.
  • The exact pro- or anti-apoptotic nature of Daxx is not definitively established.
  • Uncertainty persists regarding Daxx's functions beyond apoptosis.

Conclusions:

  • Daxx is a protein with poorly defined functions, implicated in various cellular activities.
  • Further research is required to consolidate the roles of Daxx in apoptosis and other cellular processes.
  • The unique nature of Daxx necessitates novel approaches for functional characterization.

Related Experiment Videos