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Malformations of cortical development and epilepsy.

R I Kuzniecky1, A J Barkovich

  • 1UAB Epilepsy Center, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. rkuzniecky@uabmc.edu

Brain & Development
|February 28, 2001
PubMed
Summary

Malformations of cortical development are a common cause of epilepsy and developmental delay in young people. Advances in neuroimaging and neurobiology aid in understanding these brain abnormalities.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Pediatrics

Background:

  • Malformations of cortical development (MCDs) were once considered rare but are now recognized as a significant cause of pediatric epilepsy and developmental delay.
  • Recent advancements in neuroimaging and developmental neurobiology have provided crucial tools for investigating these conditions.

Purpose of the Study:

  • This review aims to discuss common MCDs associated with epilepsy.
  • The focus is on their clinical features, classification, imaging characteristics, and underlying neurobiology.

Main Methods:

  • This is a review article, synthesizing existing knowledge.
  • It integrates findings from neuroimaging studies and developmental neurobiology research.

Main Results:

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  • The review details common MCDs linked to epilepsy, covering their clinical presentations.
  • It outlines their classification systems and characteristic appearances on neuroimaging.
  • Basic neurobiological mechanisms underlying these malformations are also discussed.

Conclusions:

  • Malformations of cortical development are increasingly identified as key factors in childhood epilepsy and developmental disorders.
  • The study of MCDs has spurred advancements in neuroimaging and our understanding of brain development.