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Updated: Jul 16, 2026

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Published on: October 2, 2019
Donepezil-induced REM sleep augmentation enhances memory performance in elderly, healthy persons
M Schredl1, B Weber, M L Leins
1Sleep Laboratory, Central Institute of Mental Health, P.O. Box 122120, 68072, Mannheim, Germany. schredl@as200.zi-mannheim.de
Donepezil, an acetylcholinesterase inhibitor, significantly improves REM sleep in the elderly. This study highlights a crucial link between enhanced REM sleep and better memory performance in older adults.
Area of Science:
- Neuroscience
- Gerontology
- Pharmacology
Background:
- Acetylcholinesterase inhibitors are known to affect sleep in younger populations.
- Previous studies suggest a role for REM sleep in cognitive function.
Purpose of the Study:
- To investigate the effects of donepezil on REM sleep parameters in the elderly.
- To explore the relationship between REM sleep and cognitive performance in older adults.
Main Methods:
- The study administered donepezil to elderly participants.
- REM sleep parameters including percentage of REM sleep, REM density, and REM latency were measured.
- Cognitive performance, specifically memory, was assessed.
Main Results:
- Donepezil treatment led to a significant increase in the percentage of REM sleep and REM density.
- REM latency was reduced in elderly individuals treated with donepezil.
- A positive correlation was observed between memory performance and REM sleep metrics.
Conclusions:
- Donepezil positively impacts REM sleep in the elderly.
- There is an interrelationship between cognitive performance and REM sleep in elderly humans.
- Findings support the role of REM sleep in maintaining cognitive function in aging populations.
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